Tadalafil
Onset
Onset, Absorption, Bioavailability
Cialis is readily absorbed from the bloodstream. It is about 16% bioavailable.
Tadalafil is about 94% bound to plasma protein. Maximum plasma concentration
of Tadalafil was achieved 2 hours post dose. The Cialis label states that
it can be taken from 30 minutes to 12 hours prior to sexual activity.
Efficacy of tadalafil may persist up to 24 hours post-dose.
Metabolism, Half Life, Excretion
Cialis is mostly metabolized in the liver by an enzyme known as CYP3A4
and to a lesser extent CYPC2. Vardenafil breakdown products are excreted
in the feces (61%) and in the urine (36%). Cialis' mean half life is 17.5
hours in healthy men.
If you are going to take any of the PDE5 inhibitors such as Cialis, it
is very important that your doctor be aware if you have a liver condition
(such as cirrhosis) or kidney condition (such as if you are on dialysis)
because you may need a special dosage adjustment.
Likewise, if you try to obtain Cialis
on the internet, please make sure that the person authorizing your prescription
knows the true status of your liver function and your kidney function.
Dose:
Cialis is available 10mg and 20mg tablets. The recommended dose is 10mg
taken prior to anticipated sexual activity and without regard to food.
In those patients in whom tadalafil 10mg does not produce an adequate
effect, 20mg might be tried. It can be taken from 30 minutes to 12 hours
prior to sexual activity. The efficacy of tadalafil may persist up to
24 hours post-dose.
The maximum recommended dose is one pill per day. |
